Indication:
Management of type 2 diabetes mellitus.
Dosage & Administration:
Adults : Starting dose of Comet® (Metformin Hydrochloride Tablet) is 500 mg twice a day or 850 mg once a day, given with meals.
Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day, given in
divided doses. Starting dose of Comet® XR (Metformin Hydrochloride Extended Release Tablet) is 500 mg once daily with the evening
meal. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal.
If glycemic control is not achieved on Comet® XR 2000 mg once daily, a trial of Comet® XR 1000 mg twice daily should be
considered. Pediatrics : Starting dose of Comet® is 500 mg twice a day, given with meals. Dosage increases should be made in
increments of 500 mg weekly up to a maximum of 2000 mg per day, given in divided doses.
Preparation:
Comet® 500 : Box containing 10 x 10 tablets in blister pack.
Comet® 850 : Box containing 5 x 10 tablets in blister pack.
Comet® XR 500 : Box containing 5 x 10 tablets in blister pack.
Comet® XR 1gm : Box containing 5 x 6 tablets in blister pack.
