Indication:

Management of type 2 diabetes mellitus.

Dosage & Administration:

Adults : Starting dose of Comet® (Metformin Hydrochloride Tablet) is 500 mg twice a day or 850 mg once a day, given with meals.

Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day, given in

divided doses. Starting dose of Comet® XR (Metformin Hydrochloride Extended Release Tablet) is 500 mg once daily with the evening

meal. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal.

If glycemic control is not achieved on Comet® XR 2000 mg once daily, a trial of Comet® XR 1000 mg twice daily should be

considered. Pediatrics : Starting dose of Comet® is 500 mg twice a day, given with meals. Dosage increases should be made in

increments of 500 mg weekly up to a maximum of 2000 mg per day, given in divided doses.

Preparation:

Comet® 500 : Box containing 10 x 10 tablets in blister pack.

Comet® 850 : Box containing 5 x 10 tablets in blister pack.

Comet® XR 500 : Box containing 5 x 10 tablets in blister pack.

Comet® XR 1gm : Box containing 5 x 6 tablets in blister pack.